Author:
Xu Jiqu,Zhou Xiaoqi,Chen Chang,Deng Qianchun,Huang Qingde,Yang Jin'e,Yang Nianhong,Huang Fenghong
Abstract
Abstract
Background
Constipation is a very common health problem in the world. Intake of sufficient amount of dietary fibers is a cornerstone in the prevention and treatment of constipation. As a traditional medicine, flaxseed has been used to treat constipation for centuries, but the controlled trials are rare. The purpose of the present study was to assess that whether partially defatted flaxseed meal (PDFM) has the potential role to facilitate fecal output in normal and experimental constipated mice.
Methods
After supplemented with 2.5%, 5% and 10% (w/w) PDFM (L-, M- and H -PDFM) for 14 days, the constipation models of mice were induced by atropine-diphenoxylate. The small intestinal transit rates, start time of defecation, amount of defecation and wet weight of feces were researched in normal and constipation model mice.
Results
M- and H-PDFM significantly increase small intestinal transit rates in constipation model mice. All dose of PDFM markedly shortened the start time of defecation and M- and H-PDFM significantly increase stool frequency and weight in both normal and constipation model mice.
Conclusions
PDFM may be a useful laxative to facilitate fecal output in normal and constipation conditions.
Publisher
Springer Science and Business Media LLC
Subject
Complementary and alternative medicine,General Medicine
Cited by
38 articles.
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