Author:
Kheirelseid Elrasheid AH,Boggs Jennifer ME,Curran Catherine,Glynn Ronan W,Dooley Cara,Sweeney Karl J,Kerin Michael J
Abstract
Abstract
Background
The debate continues as to whether younger women who present with breast cancer have a more aggressive form of disease and a worse prognosis. The objectives of this study were to determine the incidence of breast cancer in women under 40 years old and to analyse the clinicopathological characteristics and outcome compared to an older patient cohort.
Methods
Data was acquired from a review of charts and the prospectively reviewed GUH Department of Surgery database. Included in the study were 276 women diagnosed with breast cancer under the age of forty and 2869 women over forty. For survival analysis each women less than 40 was matched with two women over forty for both disease stage and grade.
Results
The proportion of women diagnosed with breast cancer under the age of forty in our cohort was 8.8%. In comparison to their older counterparts, those under forty had a higher tumour grade (p = 0.044) and stage (p = 0.046), a lower incidence of lobular tumours (p < 0.001), higher estrogen receptor negativity (p < 0.001) and higher HER2 over-expression (p = 0.002); there was no statistical difference as regards tumour size (p = 0.477). There was no significant difference in overall survival (OS) for both groups; and factors like tumour size (p = 0.026), invasion (p = 0.026) and histological type (p = 0.027), PR (p = 0.031) and HER2 (p = 0.002) status and treatment received were independent predictors of OS
Conclusion
Breast cancer in younger women has distinct histopathological characteristics; however, this does not result in a reduced survival in this population.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Reference50 articles.
1. Parkin DM, Bray F, Ferlay J, Pisani P: Global cancer statistics, 2002. Ca-a Cancer Journal for Clinicians. 2005, 55 (2): 74-108. 10.3322/canjclin.55.2.74.
2. Swanson GM, Lin CS: Survival patterns among younger women with breast cancer: the effects of age, race, stage, and treatment. J Natl Cancer Inst Monogr. 1994, 16: 69-77.
3. Brinton LA, Sherman ME, Carreon JD, Anderson WF: Recent Trends in Breast Cancer Among Younger Women in the United States. Journal of the National Cancer Institute. 2008, 100 (22): 1643-1648. 10.1093/jnci/djn344.
4. Chung M, Chang HR, Bland KI, Wanebo HJ: Younger women with breast carcinoma have a poorer prognosis than older women. Cancer. 1996, 77 (1): 97-103. 10.1002/(SICI)1097-0142(19960101)77:1<97::AID-CNCR16>3.0.CO;2-3.
5. Sidoni A, Cavaliere A, Bellezza G, Scheibel M, Bucciarelli E: Breast cancer in young women: clinicopathological features and biological specificity. Breast. 2003, 12 (4): 247-250. 10.1016/S0960-9776(03)00095-X.
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