Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells

Author:

Staab Adrian,Loeffler Jürgen,Said Harun M,Diehlmann Désirée,Katzer Astrid,Beyer Melanie,Fleischer Markus,Schwab Franz,Baier Kurt,Einsele Hermann,Flentje Michael,Vordermark Dirk

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

Reference28 articles.

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2. Koukourakis MI, Bentzen SM, Giatromanolaki A, Wilson GD, Daley FM, Saunders MI, Dische S, Siviridis E, Harris AL: Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J Clin Oncol. 2006, 24: 727-735. 10.1200/JCO.2005.02.7474.

3. Loncaster JA, Harris AL, Davidson SE, Logue JP, Hunter RD, Wycoff CC, Pastorek J, Ratcliffe PJ, Stratford IJ, West CM: Carbonic Anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 2001, 61: 6394-6399.

4. Brennan DJ, Jirstrom K, Kronblad A, Milikan RC, Landberg G, Duffy MJ, Ryden L, Gallagher WM, O'Brien SL: CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance. Clin Cancer Res. 2006, 12: 6421-6431. 10.1158/1078-0432.CCR-06-0480.

5. Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, Becker A, Adam M, Molls M, Dunst J, Terris DJ, Overgaard J: Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol. 2005, 77: 18-24. 10.1016/j.radonc.2005.06.038.

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