Author:
Zhao Huiyu,Li Hongqiu,Liang Shuo,Wang Xinyue,Yang Feng
Abstract
Abstract
Background
We aimed to analyze the distribution of knee cartilage degeneration in young patients with mild symptoms using quantitative magnetic resonance imaging (MRI) T2 mapping.
Materials and methods
This study included sixty six patients (case group) and twenty eight healthy volunteers (control group). The participants underwent 3.0 T conventional MRI plus a multi-echo sequence. The cartilage of each participant was divided into twenty eight subregions. We then calculated the T2 mean values and standard deviation or median and quartile range for each subregion according to whether the normal distribution was satisfied. Besides, we employed Kruskal–Wallis test to determine the statistical differences of each subregion in the control group while the Mann–Whitney U test was used to define the statistical difference between the case group and the control group and between the control group and subjects aged less than or equal to 35 years in the case group.
Results
In the case group, age of 30 male patients was 31.5 ± 9.3 and age of 36 female patients was 35.7 ± 8.3. In the two groups, the superficial central lateral femoral region exhibited relatively high T2 values (control/case group: 49.6 ± 2.7/55.9 ± 8.8), and the deep medial patellar region exhibited relatively low T2 values (control/case group: 34.2 ± 1.3/33.5(32.2, 35.5)). Comparison of the T2 values between the case and the control group demonstrated a statistically significant increase in nine subregions (P1 < 0.05) and there were five subregions in the case group with age ≤ 35 years (P2 < 0.05). In particular, the p-values for four subregions of the patellofemoral joint were all less than 0.05 (P1 = 0.002, 0.015, 0.036, 0.005).
Conclusion
T2 values of patients were significantly different with values of healthy groups, especially in the superficial cartilage of the patellofemoral joint. It made T2 mapping helpful to early identify patients with knee cartilage degeneration.
Funder
Liaoning Provincial Department of Education Basic Science Research Project
Middle-aged and Youth Science and Technology Innovative Talents of Shenyang City
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging
Reference41 articles.
1. Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115–26.
2. Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014;73(9):1659–64.
3. Qiu L, Perez J, Emerson C, et al. Biochemical changes in knee articular cartilage of novice half-marathon runners. J Int Med Res. 2019;47:5671–9.
4. Waldenmeier L, Evers C, Uder M, et al. Using cartilage MRI T2-mapping to analyze early cartilage degeneration in the knee joint of young professional soccer players. Cartilage. 2019;10(3):288–98.
5. Hanna S, David S, Leonie W, et al. Regions at risk in the knee joint of young professional soccer players: longitudinal evaluation of early cartilage degeneration by quantitative T2 mapping in 3 T MRI. Cartilage. 2020;1947603520924773.
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