Author:
das Chagas e Silva de Carvalho Luis Felipe,Farina Vitor Hugo,Cabral Luiz Antonio Guimarães,Brandão Adriana Aigotti Haberbeck,Coletta Ricardo Della,Almeida Janete Dias
Abstract
Abstract
Background
Melanoacanthoma (MA) has been described in the oral mucosa as a solitary lesion or, occasionally, as multiple lesions. MA mainly affects dark skinned patients and grows rapidly, showing a plane or slightly raised appearance and a brown to black color. The differential diagnosis includes oral nevi, amalgam tattoos, and melanomas. We report here the case of a 58-year-old black woman who presented multiple pigmented lesions on the hard palate.
Case presentation
Based on the differential diagnosis of melanoma, a punch biopsy (4 mm in diameter) was performed. The material was fixed in 10% formalin, embedded in paraffin, and stained with hematoxylin-eosin or submitted to immunohistochemical analysis. Immunohistochemistry using antibodies against protein S-100, melan-A, HMB-45, MCM-2, MCM-5, Ki-67 and geminin was performed. Immunohistochemical analysis revealed strong cytoplasmic immunoreactivity of dendritic melanocytes for proteinS-100, HMB-45 and melan-A.Positive staining for proliferative markers (MCM-2, MCM-5, Ki-67) was only observed in basal and suprabasal epithelial cells, confirming the reactive etiology of the lesion. The diagnosis was oral Melanoacanthoma (MA).
Conclusion
The patient has been followed up for 30 months and shows no clinical alterations. MA should be included in the differential diagnosis of pigmented lesions of the oral cavity.
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference15 articles.
1. Mishima Y, Pinkus H: Benign mixed tumor of melanocytes and malpighian cells. Melanoacanthoma: Its relationship to Bloch's benign non-nevoid melanoepithelioma. Arch Dermatol. 1960, 81: 539-550. 10.1001/archderm.1960.03730040043009.
2. Contreras E, Carlos R: Oral melanoacanthosis (melanoacanthoma): report of a case and review of literature. Med Oral Patol Oral Cir Bucal. 2005, 10: 11-12. 9–11
3. Schneider LC, Mesa ML, Haber SM: Melanoacanthoma of the oral mucosa. Oral Surg Oral Med Oral Pathol. 1981, 52: 284-287. 10.1016/0030-4220(81)90267-X.
4. Brooks JK, Sindler AJ, Papadimitriou JC, Francis LA, Scheper MA: Multifocal melanoacanthoma of the gingiva and hard palate. J Periodontol. 2009, 80: 527-532. 10.1902/jop.2009.080496.
5. Carlos-Bregni R, Contreras E, Netto AC, Mosqueda-Taylor A, Vargas PA, Jorge J, et al: Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature and immunohistochemical analysis. Med Oral Patol Oral Cir Bucal. 2007, 12: E374-E379.
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献