Malignant transformation of Madelung’s disease in a patient with a coincidental diagnosis of breast cancer: a case report

Author:

Borriello Maddalena,Lucidi Alessandro,Carbone Arnaldo,Iannone Vito,Ferrandina Gabriella

Abstract

Abstract Abstract Madelung’s disease or multiple symmetric lipomatosis (MSL) is a rare disorder of unknown etiology which typically presents symmetrically subcutaneous accumulation of non-encapsulated adipose tissue which slowly grows around the neck, upper part of the arms, pelvis, back and thigh. This disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways. Nevertheless, only one description of malignant transformation of Madelung’s disease has been presented in literature. Here, we report a case of liposarcomatous transformation of Madelung’s disease in a 59-year-old Italian woman with a coincidental diagnosis of breast cancer. Virtual slide The virtual slide for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3480884087499351

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Histology,Pathology and Forensic Medicine

Reference13 articles.

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3. Zancanaro C, Sbarbati A, Morroni M, Carraro R, Cigolini M, Enzi G, Cinti S: Multiple symmetric lipomatosis Ultrastructural investigation of the tissue and preadipocytes in primary culture. Lab Invest. 1990, 63 (2): 253-258.

4. Sia KJ, Tang IP, Tan TY: Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012, 15: 1-3.

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