Author:
Hsieh Tsan-Yu,ChangChien Yi-Che,Chen Wen-Hsiang,Chen Siu-Chung,Chang Liang-Che,Hwang Cheng-Cheng,Chein Hui-Ping,Chen Jim-Ray
Abstract
Abstract
The kidney is a relatively infrequent site for solitary fibrous tumor (SFT). Among the previously reported cases, only two cases of malignant renal SFT developing via dedifferentiation from a pre-existing benign SFT have been reported. Here we reported a case of de novo malignant renal SFT clinically diagnosed as renal cell carcinoma in a 50-year-old woman. The tumor was circumscribed but unencapsulated and showed obvious hemorrhagic necrosis. Microscopically, the tumor was composed of patternless sheets of alternating hypercellular and hypocellular areas of spindle cells displaying mild to moderate nuclear atypia, frequent mitoses up to 8 per 10 high power fields, and a 20% Ki-67 proliferative index. Immunohistochemical studies revealed reactivity for CD34, CD99 and vimentin, with no staining for all other markers, confirming the diagnosis of SFT. No areas of dedifferentiation were seen after extensive sampling. Based on the pathologic and immunohistochemical features, a diagnosis of de novo malignant renal SFT was warranted. Our report expands the spectrum of malignant progression in renal SFTs. Even though this patient has been disease-free for 30 months, long-term follow-up is still mandatory.
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Histology,Pathology and Forensic Medicine
Reference16 articles.
1. Chan JK: Solitary fibrous tumour--everywhere, and a diagnosis in vogue. Histopathology. 1997, 31: 568-76. 10.1046/j.1365-2559.1997.2400897.x.
2. Weiss SW, Goldblum JR: Soft tissue tumors of intermediate malignancy of uncertain type. Soft Tissue Tumor. Edited by: Weiss SW, Goldblum JR. 2008, Philadephia: Mosby Elsevier, 1093-1160. 5
3. Vallat-Decouvelaere AV, Dry SM, Fletcher CD: Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol. 1998, 22: 1501-11. 10.1097/00000478-199812000-00007.
4. Guillou LFJ, Fletcher CDM, Mandahi N: Extrapleural solitary fibrous tumour and hemangiopericytoma. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone. Edited by: Fletcher CDM, Unni KK, Mertens F. 2002, Lyon: IARCPress, 86-90.
5. England DM, Hochholzer L, McCarthy MJ: Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol. 1989, 13: 640-58. 10.1097/00000478-198908000-00003.
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