Author:
Gonzalez-Cuyar Luis F,Cresswell Nathaniel B,Burke Allen P
Abstract
Abstract
In this short report we illustrate a case of extensive sodium polystyrene sulfonate (SPS) aspiration as an immediate cause of death in a terminally ill patient. SPS is a cation exchange resin utilized to decrease potassium levels in patients with renal failure. When administered rectally in conjunction with sorbitol, colonic necrosis and perforation have been documented. On the other hand, oral administration can be complicated by aspiration, especially in very ill or debilitated patients. In our current report, histological examination of a patient who aspirated SPS shows multiple polygonal to amorphous basophilic crystalline particles deposited intraalveolarly. The purpose of our report is to familiarize pathologists with the histologic features of this rare iatrogenic complication of therapy for hyperkalemia.
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Histology,Pathology and Forensic Medicine
Reference25 articles.
1. Gerstman BB, Platt R: Use of sodium polystyrene sulfonate in sorbitol in the United States, 1985–1989. Am J Kidney Dis. 1991, 18 (5): 619-20.
2. Osawa A, Okoshi M, Higuchi J, Yamayoshi W: [Treatment of hyperkalemia in renal insufficiency with cation exchange resin. Experience with use of sodium polystyrene sulfonate]. Hinyokika Kiyo. 1969, 15 (9): 645-51.
3. Takasu T: [Treatment of hyperkalemia associated with renal insufficiency – clinical effects and side reactions of positive-ion-exchange resins, sodium polystyrene sulfonate (Kayexalate)]. Nippon Rinsho. 1970, 28 (7): 1941-6.
4. Linakis JG, Hull KM, Lacouture PG, Lockhart GR, Lewander WJ, Maher TJ: Sodium polystyrene sulfonate treatment for lithium toxicity: effects on serum potassium concentrations. Acad Emerg Med. 1996, 3 (4): 333-7.
5. Linakis JG, Hull KM, Lacouture PG, Lockhart GR, Lewander WJ, Maher TJ: Enhancement of lithium elimination by multiple-dose sodium polystyrene sulfonate. Acad Emerg Med. 1997, 4 (3): 175-8.
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献