Author:
Gonzalez-Cuyar Luis F,Tavora Fabio,Burke Allen P,Gocke Christopher D,Zimrin Ann,Sauk John J,Zhao Xiafeng F
Abstract
Abstract
Background
Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of hematological diseases arising in context of immunosuppression after organ transplantation. PTLD can involve any organ; however, it is extremely rare in oral cavity.
Methods
Using morphologic and immunophenotypic approaches we have studied a case of monomorphic PTLD of the tongue that developed in a patient following unilateral kidney and pancreas transplantation on immunosuppressive therapy. Additionally, cases of PTLD in the oral cavity were reviewed in the English literature.
Results
The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridization for Epstein-Barr virus was positive. Complete remission was obtained after decreasing immunosuppressive therapy. The patient remained in remission at 790 days' follow up.
Conclusion
This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Histology,Pathology and Forensic Medicine
Reference31 articles.
1. Taylor AL, Marcus R, Bradley JA: Post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation. Crit Rev Oncol Hematol. 2005
2. Preiksaitis JK: New developments in the diagnosis and management of posttransplantation lymphoproliferative disorders in solid organ transplant recipients. Clin Infect Dis. 2004, 39 (7): 1016-1023. 10.1086/424447.
3. Allen U, Hebert D, Moore D, Dror Y, Wasfy S: Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplant recipients, 1988-97: a Canadian multi-centre experience. Pediatr Transplant. 2001, 5 (3): 198-203. 10.1034/j.1399-3046.2001.00059.x.
4. Burnet FM: Immunological aspects of malignant disease. Lancet. 1967, 1 (7501): 1171-1174. 10.1016/S0140-6736(67)92837-1.
5. Penn I, Hammond W, Brettschneider L, Starzl TE: Malignant lymphomas in transplantation patients. Transplant Proc. 1969, 1 (1): 106-112.
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献