Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy (1H MRS)

Author:

Tan Giles MY,Beacher Felix,Daly Eileen,Horder Jamie,Prasher Verinder,Hanney Maria-Luisa,Morris Robin,Lovestone Simon,Murphy Kieran C,Simmons Andrew,Murphy Declan GM

Publisher

Springer Science and Business Media LLC

Subject

Cognitive Neuroscience,Neurology (clinical),Pathology and Forensic Medicine,Pediatrics, Perinatology and Child Health

Reference74 articles.

1. Wisniewski KE: Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis. Am J Med Genet Suppl. 1990, 7: 274-281.

2. Schupf N, Sergievsky GH: Genetic and host factors for dementia in Down’s syndrome. Br J Psychiatry. 2002, 180: 405-410. 10.1192/bjp.180.5.405.

3. Visser FE, Aldenkamp AP, van Huffelen AC, Kuilman M, Overweg J, van Wijk J: Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome. Am J Ment Retard. 1997, 101: 400-412.

4. Margallo-Lana ML, Moore PB, Kay DW, Perry RH, Reid BE, Berney TP, Tyrer SP: Fifteen-year follow-up of 92 hospitalized adults with Down’s syndrome: incidence of cognitive decline, its relationship to age and neuropathology. J Intellect Disabil Res. 2007, 51: 463-477. 10.1111/j.1365-2788.2006.00902.x.

5. Sheehan R, Ali A, Hassiotis A: Dementia in intellectual disability. Curr Opin Psychiatry. 2014, 27: 143-148. 10.1097/YCO.0000000000000032.

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