Author:
de Sousa Bruno Rafael Virginio,de Lima Tavares Toscano Lydiane,de Almeida Filho Eder Jackson Bezerra,Sena Klécia Farias,Costa Matheus Silveira,de Souza Cunha Rebeka Correia,de Souza Siqueira Quintans Jullyana,Heimfarth Luana,Marques Aline Telles Biasoto,da Silva Darcilene Fiuza,de Campos Luis Felipe Castelli Correia,Persuhn Darlene Camati,Silva Alexandre Sérgio
Abstract
Abstract
Background
We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-to-exhaustion running test, redox balance and muscle damage in recreational runners.
Methods
Forty-seven male recreational runners performed a running test until exhaustion after supplementation with grape juice or a control drink. Serum total antioxidant capacity (TAC), malondialdehyde (MDA), plasma nitrite (NO), creatine kinase (CK) and lactate dehydrogenase (LDH) were measured pre and post exercise. Also, polymorphisms were analyzed in DNA extracted from the oral mucosa.
Results
Grape juice improved the time-to-exhaustion. When analyzed by genotype, the recreational runners with GG+CG genotypes of the SOD3 gene had greater time-to-exhaustion than the CC genotype, but was no different for the PAPRα gene. A slight difference was noted in TAC, since the CC genotype of the SOD3 gene showed higher TAC values in the post-exercise compared to the baseline and with pre-exercise, but these values did not increase compared to the CG+GG group, respectively. The SOD3 and PPARα genes were similar at all times for the other biochemical variables.
Conclusion
The ergogenic effect of grape juice was genotype-dependent for SOD3 Arg213Gly. However, biochemical redox balance markers did not explain this difference.
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Endocrinology, Diabetes and Metabolism
Cited by
1 articles.
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