Author:
Zakerinasab Faezeh,Behfar Qumars,Parsaee Reza,Zadeh Reza Hossein,Foroughi Elaheh,Amirbeik Amirhesam,Ahmadi Ghazalehsadat
Abstract
Abstract
Purpose
In this study, we aim to investigate the association between BRCA1/2 mutation and uterine cancer incidence.
Material and method
We systematically searched three databases including PubMed, Scopus, and Google Scholar up to August 2023; and reviewed 23 cohorts and cross-sectional studies to explore the association between BRCA1/2 mutations and uterine cancer incidence.
Results
This systematic review comprised a total of 21 cohort studies and 2 cross-sectional studies after the screening process. According to meta-analysis the prevalence of the BRCA1/2 gene in patients with uterine cancer was 0.02 (95%CI = [0.01,0.03], P < 0.01, I2 = 94.82%)
Conclusions
Our meta-analysis investigates a 2% prevalence of BRCA1/2 mutation in patients with uterine cancer. Patients with BRCA1/2 mutations might be more conscious of uterine malignancies.
Publisher
Springer Science and Business Media LLC
Subject
Health Informatics,Genetics