Author:
Hu Wei,Liu Cong,Bi Zhuo-Yue,Zhou Qun,Zhang Han,Li Lin-Lin,Zhang Jian,Zhu Wei,Song Yang-Yi-Yan,Zhang Feng,Yang Hui-Min,Bi Yong-Yi,He Qi-Qiang,Tan Gong-Jun,Sun Cheng-Cao,Li De-Jia
Abstract
AbstractExtracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally divided into exosomes and microvesicles on basis of their origination from the endosomal membrane or the plasma membrane, respectively. EV-mediated bidirectional communication among various cell types supports cancer cell growth and metastasis. EVs derived from different cell types and status have been shown to have distinct RNA profiles, comprising messenger RNAs and non-coding RNAs (ncRNAs). Recently, ncRNAs have attracted great interests in the field of EV-RNA research, and growing numbers of ncRNAs ranging from microRNAs to long ncRNAs have been investigated to reveal their specific functions and underlying mechanisms in the tumor microenvironment and premetastatic niches. Emerging evidence has indicated that EV-RNAs are essential functional cargoes in modulating hallmarks of cancers and in reciprocal crosstalk within tumor cells and between tumor and stromal cells over short and long distance, thereby regulating the initiation, development and progression of cancers. In this review, we discuss current findings regarding EV biogenesis, release and interaction with target cells as well as EV-RNA sorting, and highlight biological roles and molecular mechanisms of EV-ncRNAs in cancer biology.
Funder
National Natural Science Foundation of China
National Postdoctoral Program for Innovative Talents
China Postdoctoral Science Foundation
the Fundamental Research Funds for the Central Universities
Health Commission of Hubei Province scientific research project
Hubei Province Key Laboratory of Occupational Hazard Identification and Control
the Wuhan University Startup Funds, and the Independent Research Funds of School of Health Sciences at Wuhan University
Health Commission of Wuhan City Scientific Research Project
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine
Cited by
153 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献