Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

Author:

Hu Wei,Liu Cong,Bi Zhuo-Yue,Zhou Qun,Zhang Han,Li Lin-Lin,Zhang Jian,Zhu Wei,Song Yang-Yi-Yan,Zhang Feng,Yang Hui-Min,Bi Yong-Yi,He Qi-Qiang,Tan Gong-Jun,Sun Cheng-Cao,Li De-Jia

Abstract

AbstractExtracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally divided into exosomes and microvesicles on basis of their origination from the endosomal membrane or the plasma membrane, respectively. EV-mediated bidirectional communication among various cell types supports cancer cell growth and metastasis. EVs derived from different cell types and status have been shown to have distinct RNA profiles, comprising messenger RNAs and non-coding RNAs (ncRNAs). Recently, ncRNAs have attracted great interests in the field of EV-RNA research, and growing numbers of ncRNAs ranging from microRNAs to long ncRNAs have been investigated to reveal their specific functions and underlying mechanisms in the tumor microenvironment and premetastatic niches. Emerging evidence has indicated that EV-RNAs are essential functional cargoes in modulating hallmarks of cancers and in reciprocal crosstalk within tumor cells and between tumor and stromal cells over short and long distance, thereby regulating the initiation, development and progression of cancers. In this review, we discuss current findings regarding EV biogenesis, release and interaction with target cells as well as EV-RNA sorting, and highlight biological roles and molecular mechanisms of EV-ncRNAs in cancer biology.

Funder

National Natural Science Foundation of China

National Postdoctoral Program for Innovative Talents

China Postdoctoral Science Foundation

the Fundamental Research Funds for the Central Universities

Health Commission of Hubei Province scientific research project

Hubei Province Key Laboratory of Occupational Hazard Identification and Control

the Wuhan University Startup Funds, and the Independent Research Funds of School of Health Sciences at Wuhan University

Health Commission of Wuhan City Scientific Research Project

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Molecular Medicine

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