Abstract
AbstractN6-methyladenosine (m6A), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently closed RNA molecules characterized by universality, diversity, stability and conservatism of evolution. Accumulating evidence shows that both m6A modification and circRNAs participate in the pathogenesis of multiple diseases, such as cancers, neurological diseases, autoimmune diseases, and infertility. Recently, m6A modification has been identified for its enrichment and vital biological functions in regulating circRNAs. In this review, we summarize the role of m6A modification in the regulation and function of circRNAs. Moreover, we discuss the potential applications and possible future directions in the field.
Funder
National Natural Science Foundation of China
Key Scientific Research Projects of Institutions of Higher Education in Henan Province
Medical Scientific and Technological Research Project of Henan Province
Postdoctoral Research Foundation of China
National Natural Science Foundation of Henan Province
Health Commission Technology Talents Overseas Training Project of Henan Province
Key Scientific Research Project of Henan Higher Education Institutions
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine
Cited by
206 articles.
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