Author:
He Lian,Man Changfeng,Xiang Shouyan,Yao Lin,Wang Xiaoyan,Fan Yu
Abstract
AbstractCircular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement of algorithms, some CircRNAs are discovered to encode proteins through the cap-independent mechanism and participate in the important process of tumorigenesis and development. Based on an overview of CircRNAs, this paper summarizes its translation mechanism and research methods, and reviews the research progress of CircRNAs translation in the field of oncology in recent years. Moreover, this paper aims to provide new ideas for tumor diagnosis and treatment through CircRNAs translation.
Funder
jiangsu innovative team leading talent fund
jiangsu 333 talent fund
jiangsu provincial key research and development special fund
jiangsu six high peak talent fund
suqian science and technology support project fund
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine
Cited by
48 articles.
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