PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine
Link
https://link.springer.com/content/pdf/10.1186/s12943-022-01512-0.pdf
Reference10 articles.
1. Yang Y, Wu ZX, Wang JQ, Teng QX, Lei ZN, Lusvarghi S, et al. OTS964, a TOPK inhibitor, is susceptible to ABCG2-mediated drug resistance. Front Pharmacol. 2021;12:620874.
2. Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol. 1999;39:361–98.
3. Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, Gottesman MM. P-glycoprotein: from genomics to mechanism. Oncogene. 2003;22:7468–85.
4. Wu ZX, Teng QX, Cai CY, Wang JQ, Lei ZN, Yang Y, et al. Tepotinib reverses ABCB1-mediated multidrug resistance in cancer cells. Biochem Pharmacol. 2019;166:120–7.
5. Ferreira RJ, Bonito CA, Cordeiro M, Ferreira MU, Dos Santos D. Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies. Sci Rep. 2017;7:15534.
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