Author:
Han Mingyu,Sun Haifeng,Zhou Quanbo,Liu Jinbo,Hu Junhong,Yuan Weitang,Sun Zhenqiang
Abstract
AbstractTumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common modifications and is widely observed in eukaryotes and prokaryotes. Accumulating studies have revealed that RNA methylation affects the occurrence and development of various tumors. In recent years, RNA methylation has been shown to play an important role in regulating tumor angiogenesis. In this review, we mainly elucidate the mechanisms and functions of RNA methylation on angiogenesis and progression in several cancers. We then shed light on the role of RNA methylation-associated factors and pathways in tumor angiogenesis. Finally, we describe the role of RNA methylation as potential biomarker and novel therapeutic target.
Funder
The Provincial and Ministry co-constructed key projects of Henan medical science and technology
National Natural Science Foundation of China
The Science Project of Henan Natural Science Foundation
The Youth Talent Innovation Team Support Program of Zhengzhou University
Key scientific and technological research projects of Henan Provincial Department of Science and Technology
Henan Provincial Health Commission and Ministry of Health Co-construction Project, and Henan Provincial Health and Health Commission Joint Construction Project
Henan Province young and middle-aged health science and technology innovation leading talent project
Henan Province Medical Affairs Technology Promotion Project
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine