Author:
Huang Shengkang,Wang Xinyu,Wang Yu,Wang Yajing,Fang Chenglong,Wang Yazhuo,Chen Sifei,Chen Runkai,Lei Tao,Zhang Yuchen,Xu Xinjie,Li Yuhua
Abstract
AbstractChimeric antigen receptor (CAR) T-cell therapy has made remarkable progress in cancer immunotherapy, but several challenges with unclear mechanisms hinder its wide clinical application. Single-cell sequencing technologies, with the powerful unbiased analysis of cellular heterogeneity and molecular patterns at unprecedented resolution, have greatly advanced our understanding of immunology and oncology. In this review, we summarize the recent applications of single-cell sequencing technologies in CAR T-cell therapy, including the biological characteristics, the latest mechanisms of clinical response and adverse events, promising strategies that contribute to the development of CAR T-cell therapy and CAR target selection. Generally, we propose a multi-omics research mode to guide potential future research on CAR T-cell therapy.
Funder
National Students’ Platform for Innovation and Entrepreneurship Training Program of China
Guangdong Students’ Platform for Innovation and Entrepreneurship Training Program
National Key Research and Development Programof China
Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory
Basic and Applied Basic Research Fund of Guangdong Province
Special Funds for the Cultivation of Guangdong College Students’ Scientific and Technological Innovation
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献