Application of fibrin-based hydrogels for nerve protection and regeneration after spinal cord injury

Author:

Yu Ziyuan,Li Hongru,Xia Peng,Kong Weijian,Chang Yuxin,Fu Chuan,Wang Kai,Yang XiaoyuORCID,Qi Zhiping

Abstract

AbstractTraffic accidents, falls, and many other events may cause traumatic spinal cord injuries (SCIs), resulting in nerve cells and extracellular matrix loss in the spinal cord, along with blood loss, inflammation, oxidative stress (OS), and others. The continuous development of neural tissue engineering has attracted increasing attention on the application of fibrin hydrogels in repairing SCIs. Except for excellent biocompatibility, flexibility, and plasticity, fibrin, a component of extracellular matrix (ECM), can be equipped with cells, ECM protein, and various growth factors to promote damage repair. This review will focus on the advantages and disadvantages of fibrin hydrogels from different sources, as well as the various modifications for internal topographical guidance during the polymerization. From the perspective of further improvement of cell function before and after the delivery of stem cell, cytokine, and drug, this review will also evaluate the application of fibrin hydrogels as a carrier to the therapy of nerve repair and regeneration, to mirror the recent development tendency and challenge.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Biomedical Engineering,Environmental Engineering

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