Author:
Yuan Shuai,Li Qingshu,Chen Kaiwen,Mu Zhixiang,Chen Tao,Wang Huanan,Ji Ping
Abstract
AbstractRidge preservation is universally acknowledged as the conventional method for the post-extraction healing yet there are no standard materials for the ideal healing outcome. Herein, a composite gel comprising gelatin nanoparticles (GNPs) and injectable platelet-rich-fibrin (i-PRF) as the potential candidate for extracted socket healing is introduced. The combination of GNPs and i-PRF not only possesses favorable mechanical properties to withstand external force but also accelerate the blood clotting time significantly. In addition, six beagle dogs were adopted to assess the angiogenic and osteogenic capacity of GNPs+i-PRF gel in vivo. The GNPs+i-PRF gel significantly produced the most blood vessels area, woven bone and low osteoclast activity in extracted sockets at 2 weeks postoperation and remarkably generated corticalization on the alveolar ridge crest at 8 weeks postoperation according to histological results. Therefore, GNPs+i-PRF gel can be recommended as the candidate grafting material regarding ridge preservation for its cost effectiveness, excellent biocompatibility, facilitation of blood clotting and favorable capacity of promoting angiogenesis and osteogenesis.
Funder
National Natural Science Foundation of China
Postdoctoral Research Foundation of China
Chongqing Postdoctoral Science Special Foundation
Fundamental Research Funds for the Central Universities
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biomedical Engineering,Environmental Engineering
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