Author:
Zhu Tongtong,Niu Guangyi,Zhang Yuansheng,Chen Ming,Li Chuan-Yun,Hao Lili,Zhang Zhang
Abstract
AbstractViruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA editing, as a crucial co-/post-transcriptional modification inducing nucleotide alterations on both endogenous and exogenous RNA sequences, exerts significant influences on virus replication, protein synthesis, infectivity and toxicity. Hitherto, a number of host-mediated RNA editing sites have been identified in diverse viruses, yet lacking a full picture of RNA editing-associated mechanisms and effects in different classes of viruses. Here we synthesize the current knowledge of host-mediated RNA editing in a variety of viruses by considering two enzyme families, viz., ADARs and APOBECs, thereby presenting a landscape of diverse editing mechanisms and effects between viruses and hosts. In the ongoing pandemic, our study promises to provide potentially valuable insights for better understanding host-mediated RNA editing on ever-reported and newly-emerging viruses.
Funder
Special Investigation on Science and Technology Basic Resources of the MOST
The Youth Innovation Promotion Association of Chinese Academy of Sciences
Strategic Priority Research Program of the Chinese Academy of Sciences
International Partnership Program of the Chinese Academy of Sciences
the Open Biodiversity and Health Big Data Programme of IUBS
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Applied Mathematics,General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Immunology
Cited by
2 articles.
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