Author:
Torices Silvia,Daire Leah,Simon Sierra,Naranjo Oandy,Mendoza Luisa,Teglas Timea,Fattakhov Nikolai,Adesse Daniel,Toborek Michal
Abstract
AbstractCompromised structure and function of the blood-brain barrier (BBB) is one of the pathological hallmarks of brain infection by HIV-1. BBB damage during HIV-1 infection has been associated with modified expression of tight junction (TJ) proteins, including occludin. Recent evidence indicated occludin as a redox-sensitive, multifunctional protein that can act as both an NADH oxidase and influence cellular metabolism through AMPK kinase. One of the newly identified functions of occludin is its involvement in regulating HIV-1 infection. Studies suggest that occludin expression levels and the rate of HIV-1 infection share a reverse, bidirectional relationship; however, the mechanisms of this relationship are unclear. In this review, we describe the pathways involved in the regulation of HIV-1 infection by occludin. We propose that occludin may serve as a potential therapeutic target to control HIV-1 infection and to improve the lives of people living with HIV-1.
Funder
National Institute of Allergy and Infectious Diseases
American Heart Association Hispanic Serving Institutions Scholars Program
National Institute on Drug Abuse
Fundação Oswaldo Cruz
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Jovem Cientista do Nosso Estado
National Institute of Mental Health
National Heart, Lung, and Blood Institute
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Developmental Neuroscience,Neurology,General Medicine
Cited by
2 articles.
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