Author:
Hu Ziliang,Deng Xinpeng,Zhou Shengjun,Zhou Chenhui,Shen Menglu,Gao Xiang,Huang Yi
Abstract
AbstractCerebral vasospasm significantly contributes to poor prognosis and mortality in patients with aneurysmal subarachnoid hemorrhage. Current research indicates that the pathological and physiological mechanisms of cerebral vasospasm may be attributed to the exposure of blood vessels to toxic substances, such as oxyhaemoglobin and inflammation factors. These factors disrupt cerebral vascular homeostasis. Vascular homeostasis is maintained by the extracellular matrix (ECM) and related cell surface receptors, such as integrins, characterised by collagen deposition, collagen crosslinking, and elastin degradation within the vascular ECM. It involves interactions between the ECM and smooth muscle cells as well as endothelial cells. Its biological activities are particularly crucial in the context of cerebral vasospasm. Therefore, regulating ECM homeostasis may represent a novel therapeutic target for cerebral vasospasm. This review explores the potential pathogenic mechanisms of cerebral vasospasm and the impacts of ECM protein metabolism on the vascular wall during ECM remodelling. Additionally, we underscore the significance of an ECM protein imbalance, which can lead to increased ECM stiffness and activation of the YAP pathway, resulting in vascular remodelling. Lastly, we discuss future research directions.
Funder
Ningbo Health Branding Subject Fund
Ningbo Top Medical and Health Research Program
Natural Science Foundation of Ningbo Municipality
the Zhejiang Provincial Natural Science Foundation of China
Zhejiang Provincial TCM Science and Technology Plan Project
Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Developmental Neuroscience,Neurology,General Medicine
Cited by
1 articles.
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