Author:
Enomoto Hisako,Noguchi Emiko,Iijima Shigeruko,Takahashi Takenori,Hayakawa Kazuhito,Ito Mikako,Kano Toshiyuki,Aoki Takeshi,Suzuki Yoichi,Koga Minori,Tamari Mayumi,Shiohara Tetsuo,Otsuka Fujio,Arinami Tadao
Abstract
Abstract
Background
Atopic dermatitis develops as a result of complex interactions between several genetic and environmental factors. To date, 4 genome-wide linkage studies of atopic dermatitis have been performed in Caucasian populations, however, similar studies have not been done in Asian populations. The aim of this study was to identify chromosome regions linked to atopic dermatitis in a Japanese population.
Methods
We used a high-density, single nucleotide polymorphism genotyping assay, the Illumina BeadArray Linkage Mapping Panel (version 4) comprising 5,861 single nucleotide polymorphisms, to perform a genome-wide linkage analysis of 77 Japanese families with 111 affected sib-pairs with atopic dermatitis.
Results
We found suggestive evidence for linkage with 15q21 (LOD = 2.01, NPL = 2.87, P = .0012) and weak linkage to 1q24 (LOD = 1.26, NPL = 2.44, P = .008).
Conclusion
We report the first genome-wide linkage study of atopic dermatitis in an Asian population, and novel loci on chromosomes 15q21 and 1q24 linked to atopic dermatitis. Identification of novel causative genes for atopic dermatitis will advance our understanding of the pathogenesis of atopic dermatitis.
Publisher
Springer Science and Business Media LLC
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