Author:
Wu Chaoyang,Cai Rong,Zhao Tian,Wu Lin,Zhang Lirong,Jin Jie,Xu Lixia,Li Pengfei,Li Tao,Zhang Miaomiao,Du Fengyi
Abstract
AbstractInaccuracy localization and intrinsic radioresistance of solid tumors seriously hindered the clinical implementation of radiotherapy. In this study, we fabricated hyaluronic acid-functionalized gadolinium oxide nanoparticles (HA-Gd2O3 NPs) via one-pot hydrothermal process for effective magnetic resonance (MR) imaging and radiosensitization of tumors. By virtue of HA functionalization, the as-prepared HA-Gd2O3 NPs with a diameter of 105 nm showed favorable dispersibility in water, low cytotoxicity, and excellent biocompatibility and readily entered into the cytoplasm of cancer cells by HA receptor-mediated endocytosis. Importantly, HA-Gd2O3 NPs exhibited high longitudinal relaxivity (r1) 6.0 mM−1S−1 as MRI contrast agents and radiosensitization enhancement in a dose-dependent manner. These finds demonstrated that as-synthesized HA-Gd2O3 NPs as bifunctional theranostic agents have great potential in tumors diagnosis and radiotherapy.
Funder
Six talent peaks project in Jiangsu Province
Key talents of Medical Science in Jiangsu Province project
Key research projects of natural science in colleges and universities in jiangsu province
Scientific research projects of college students
Zhenjiang key research and development plan
Major projects of natural science research in Colleges and universities of Jiangsu Province
Publisher
Springer Science and Business Media LLC
Subject
Condensed Matter Physics,General Materials Science
Cited by
20 articles.
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