Author:
Liu Zihao,Xia Qian,Ma Dengzhen,Wang Zhihai,Li Longji,Han Min,Yin Xianyong,Ji Xiaoshuai,Wang Shan,Xin Tao
Abstract
AbstractIschemic stroke is one of the most severe neurological disorders with limited therapeutic strategies. The utilization of nanoparticle drug delivery systems is a burgeoning field and has been widely investigated. Among these, biomimetic drug delivery systems composed of biogenic membrane components and synthetic nanoparticles have been extensively highlighted in recent years. Biomimetic membrane camouflage presents an effective strategy to prolong circulation, reduce immunogenicity and enhance targeting. For one thing, biomimetic nanoparticles reserve the physical and chemical properties of intrinsic nanoparticle. For another, the biological functions of original source cells are completely inherited. Compared to conventional surface modification methods, this approach is more convenient and biocompatible. In this review, membrane-based nanoparticles derived from different donor cells were exemplified. The prospect of future biomimetic nanoparticles in ischemic stroke therapy was discussed.Graphic abstract
Funder
Innovation Project of Clinical Science and Technology of Jinan City
National Natural Science Foundation of China
Academic promotion program of Shandong First Medical University
Publisher
Springer Science and Business Media LLC
Cited by
6 articles.
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