Author:
Sun Nan,Wang Chunxi,Linghu Wenrui,Li Xiaorong,Zhang Xiaomin
Abstract
Abstract
Background
To analyse demographic, clinical features, treatment and therapeutic outcomes of pediatric uveitis and scleritis patients.
Subjects
The clinical records of pediatric uveitis and scleritis cases between January 2012 and December 2020 at a tertiary uveitis service center in Tianjin Medical University Eye Hospital (TMUEH) were reviewed.
Results
In total, 209 patients (337 eyes) were included, 49.3% were male. The median onset age was 9.0 (IQR, 7.0–12.0) years. Chronic uveitis and scleritis accounted for 86.1%. Panuveitis (29.2%), anterior uveitis(29.2%), and intermediate uveitis (22.0%) were the most common presentations. The most common diagnoses were idiopathic (71.3%), JIA (8.1%), and infectious uveitis (4.8%). At baseline, 40.7% patients received oral corticosteroid therapy; during follow-up, corticosteroids (66.0%), disease-modifying antirheumatic drugs (61.2%), and biologic agents (35.4%) were the mainstay. Posterior synechia (26.1%) and cataracts (25.5%) were the most common complications. In acute cases, the median best corrected visual acuity (BCVA) was 0.99 (IQR, 0.5–1.0) at baseline and 0 (IQR, 0–0) at last follow-up; in chronic cases, the median BCVA improved from 1.09 (IQR, 0.5–2.0) to 0.27 (IQR, 0–0.5), with anterior chamber cell grade significantly declining. Ten eyes underwent cataract surgery during regular follow-up and achieved satisfactory long-term visual outcomes and decreased burden of immunosuppressants. The incidence of steroid-induced ocular hypertension was 41.0%, and children with frequent instillation of eyedrops were at high risk.
Conclusions
Most cases were of chronic uveitis and scleritis requiring long-term systemic immunosuppressive therapies in pediatric uveitis and scleritis in China. Good management of complications is important for long-term prognosis.
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology,General Medicine
Reference45 articles.
1. Chan NS, Choi J, Cheung CMG. Pediatric Uveitis. Asia Pac J Ophthalmol (Phila). 2018;7:192–9.
2. Tarsia M, Gaggiano C, Gessaroli E, Grosso S, Tosi GM, Frediani B, et al. Pediatric Scleritis: An Update. 2022;1-10. [Epub ahead of print].
3. Waduthantri SMS, Chee SF. Pediatric Uveitis and Scleritis in a Multi-Ethnic Asian Population. 2020;29:7–8.
4. Gautam N, Singh R, Agarwal A, Yangzes S, Dogra M, Sharma A, et al. Pattern of Pediatric Uveitis at a Tertiary Referral Institute in North India. Ocul Immunol Inflamm. 2018;26:379–85.
5. Keino H, Watanabe T, Taki W, Nakayama M, Nakamura T, Yan K, et al. Clinical features of uveitis in children and adolescents at a tertiary referral centre in Tokyo. Br J Ophthalmol. 2017;101:406–10.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献