Comprehensive evaluation of functional vision, quality of life, and cognitive ability in pediatric uveitis
-
Published:2023-09-18
Issue:1
Volume:23
Page:
-
ISSN:1471-2415
-
Container-title:BMC Ophthalmology
-
language:en
-
Short-container-title:BMC Ophthalmol
Author:
Wan Wenjuan,Chen Zhijun,Xun Yan,Yi Kun,Zhu Ying,Pu Yanlin,Su Guannan,Zhou Chunjiang,Wang Yao,Yang Peizeng
Abstract
Abstract
Background
Pediatric uveitis may cause severe impairment of vision in children and affect their quality of life as well as cognitive ability. This study aims to evaluate the functional vision, visual-related and health-related quality of life, and cognitive ability in pediatric uveitis.
Methods
Children with uveitis aged 5–16 years old completed six validated instruments to assess functional visual ability with Cardiff Visual Ability Questionnaire for Children (CVAQC), vision-related quality of life with Impact of Vision Impairment for Children (IVI-C), health-related quality of life with Pediatric Quality of Life Inventory (PedsQL), cognitive ability with Chinese Wechsler Intelligence Scale for Children (C-WISC), and depression and anxiety evaluation with Hospital Anxiety and Depression Scale (HAD).
Results
The CVAQC, IVI-C, and PedsQL scores of pediatric uveitis were significantly lower than that of normal levels. Full-scale intelligence quotient (IQ) and performance IQ were significantly lower in pediatric uveitis patients with impaired vision in their best eye (visual acuity < 0.3) compared to those with a vision equal to or better than 0.3. Verbal IQ was significantly lower in male pediatric uveitis patients with impaired vision compared to those with a vision equal to or better than 0.3. Additionally, parents of pediatric uveitis patients with impaired vision generally had lower educational levels than parents of those with a vision equal to or better than 0.3.
Conclusions
Impaired vision caused by pediatric uveitis has a significant impact on children’s functional visual ability and quality of life. The development of cognitive function in pediatric uveitis is also significantly hindered.
Funder
Chongqing Key Laboratory of Ophthalmology
Chongqing Science & Technology Platform and Base Construction Program
Key Project of Chongqing Science and Technology Bureau
National Natural Science Foundation of China
Natural Science Foundation of Chongqing Science and Technology Bureau
Chongqing Outstanding Scientists Project
the Chongqing Chief Medical Scientist Project
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology,General Medicine
Reference45 articles.
1. Shome A, Mugisho OO, Niederer RL, Rupenthal ID. Blocking the inflammasome: a novel approach to treat uveitis. Drug Discov Today 2021.
2. Maleki A, Anesi SD, Look-Why S, Manhapra A, Foster CS. Pediatric uveitis: a comprehensive review. Surv Ophthalmol 2021.
3. Paivonsalo-Hietanen T, Tuominen J, Saari KM. Uveitis in children: population-based study in Finland. Acta Ophthalmol Scand. 2000;78(1):84–8.
4. Rosenberg KD, Feuer WJ, Davis JL. Ocular complications of pediatric uveitis. Ophthalmology. 2004;111(12):2299–306.
5. Majumder PD, Biswas J. Pediatric uveitis: an update. Oman J Ophthalmol. 2013;6(3):140–50.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献