Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing-Reference-Cited by-同舟云学术

Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing

Published:2024-03-04 Issue:1 Volume:24 Page:
ISSN:1471-2415
Container-title:BMC Ophthalmology
language:en
Short-container-title:BMC Ophthalmol

Author:

Wang Xiao-na,Hong Jing,Xu Yong-gen,Zhang Pei,Li Ying-yu,Dou Hong-liang,Li Hai-ping

Abstract

Abstract Purpose Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a relatively rare subtype of DLBCL. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis. Methods A 72-year-old male patient presented to our hospital with progressive blurring of vision in the left eye for the past 4 months. Small white nodular lesions were observed on the iris and retinal surface of the left eye, with a white cloud-like opacity in the vitreous cavity. Results The patient was eventually diagnosed with EBV-positive iris DLBCL after undergoing pathological and metagenomic tests. After injecting methotrexate in the left vitreous cavity and administering systemic and local antiviral treatments, the ocular lesions disappeared. Conclusion EBV infection, drug immunosuppression, and aging-related immune deterioration may play significant roles in the pathogenesis of EBV-positive iris DLBCL. Synopsis Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a new subtype of DLBCL, which rarely occurs. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis.

Funder

Clinical Medicine Plus X - Young Scholars Project,Peking University, the Fundamental Research Funds for the Central Universities

National Natural Science Foundation: The process and mechanism of corneal endothelitis caused by cytomegalovirus infection

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1186/s12886-024-03334-8.pdf

Reference21 articles.

1. Sagoo MS, Mehta H, Swampillai AJ, et al. Primary intraocular lymphoma. Surv Ophthalmol. 2014;59(5):503–16. https://doi.org/10.1016/j.survophthal.2013.12.001.

2. Silpa-archa S, Sriyuttagrai W, Foster CS. Treatment for Epstein-Barr virus-associated uveitis confirmed by polymerase chain reaction: efficacy of anti-viral agents and a literature review. J Clin Virol. 2022;147:105079. https://doi.org/10.1016/j.jcv.2022.105079.

3. Ayee R, Ofori MEO, Wright E, Quaye O. Epstein Barr virus associated lymphomas and epithelia cancers in humans. J Cancer. 2020;11(7):1737–50. https://doi.org/10.7150/jca.37282.

4. Hatton OL, Harris-Arnold A, Schaffert S, Krams SM, Martinez OM. The interplay between Epstein-Barr virus and B lymphocytes: implications for infection, immunity, and disease. Immunol Res. 2014;58(2–3):268–76. https://doi.org/10.1007/s12026-014-8496-1.

5. Sobolewska B, Chee SP, Zaguia F, Goldstein DA, Smith JR, Fend F, Mochizuki M, Zierhut M. Vitreoretinal Lymphoma Cancers (Basel). 2021;13(16):3921. https://doi.org/10.3390/cancers13163921.