Author:
Portela Amanda Lemos Barros Martins,Moreno Rafael Neves,Ribeiro Maria Helena Madruga Lima,de Andrade Fernanda Miguel,Alves Yale Viana,Alves Mônica,Lira Rodrigo Pessoa Cavalcanti
Abstract
Abstract
Background
To investigate the effect of nicergoline on the rate of complete corneal ulcer reepithelialization (CCUR) in diabetic rats with diabetic keratopathy.
Methods
Forty-eight streptozotocin-induced diabetic rats were randomly divided into two groups. The experimental group (n = 24) received nicergoline (10 mg.kg− 1.day− 1), while the control group (n = 24) received a placebo. A corneal epithelial defect was induced using a corneal diamond burr, and defect area was compared at time points of 0, 12, 24, 48 and 72 h after the injury using image analysis software. The probability of CCUR within 72 h was assessed using the Kaplan–Meier survival analysis log-rank test.
Results
When compared, 4 of the 24 rats (17%) in the placebo group and 12 of the 24 rats (50%) in the nicergoline group were found to have CCUR within 72 h (log-rank = 0.027). Cox regression analysis found no effect of the covariates blood glucose (P = 0.601) or weight (P = 0.322) on the corneal reepithelialization (survival) curve.
Conclusions
Nicergoline increased wound healing rates relative to placebo and may therefore be investigated as a treatment option in diabetic keratopathy.
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology,General Medicine
Cited by
4 articles.
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