Author:
Yin Houfa,Chen Xinyi,Hong Xiaogang,Ma Jian,Wu Fang,Wan Ting,Sang Yiwen,Fu Qiuli,Qin Zhenwei,Lyu Danni,Wu Wei,Yin Jinfu,Yang Yabo
Abstract
Abstract
Background
To investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surgery.
Methods
Trabeculectomy was performed on both eyes of New Zealand rabbits. A decellularized lenticule was placed in the subconjunctival space in one eye of the rabbits (the decellularized lenticule group), and no adjunctive treatment was performed in the fellow eye (the control group). The filtering bleb features and IOP were evaluated 0, 3, 7, 14, 21, and 28 days after surgery, and histopathologic examination was performed 28 days after surgery.
Results
Decellularized lenticules significantly increased bleb survival and decreased IOP postoperatively in the rabbit model with no adverse side effects. The histopathologic results showed a larger subconjunctival space and less subconjunctival fibrosis in the decellularized lenticule group.
Conclusions
Decellularized lenticules can prevent postoperative conjunctiva-sclera adhesion and fibrosis, and they may represent a novel antifibrotic agent for trabeculectomy.
Funder
Natural Science Foundation of Zhejiang Province
Program of Zhejiang Medical Technology
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology,General Medicine
Reference25 articles.
1. Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S. Glaucoma. Lancet. 2017;390(10108):2183–93.
2. Grover DS, Kornmann HL, Fellman RL. Historical Considerations and Innovations in the perioperative use of Mitomycin C for Glaucoma filtration surgery and Bleb Revisions. J Glaucoma. 2020;29(3):226–35.
3. Seibold LK, Sherwood MB, Kahook MY. Wound modulation after filtration surgery. Surv Ophthalmol. 2012;57(6):530–50.
4. Al Habash A, Aljasim LA, Owaidhah O, Edward DP. A review of the efficacy of mitomycin C in glaucoma filtration surgery. Clin Ophthalmol. 2015;9:1945–51.
5. Chong RS, Crowston JG, Wong TT. Experimental models of glaucoma filtration surgery. Acta Ophthalmol. 2021;99(1):9–15.
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