Author:
Ibrahim Amina Mohamed,Abdel-Ghaffar Fathi A.,Hassan Hassan Abdel-Malek,Fol Mona Fathi
Abstract
Abstract
Background
Schistosomiasis is a major, but generally overlooked, tropical disease carried by snails of the genus Biomphalaria, which have a large distribution in Egypt. Control of the intermediate host snail is critical in limiting schistosomiasis spread. On the topic of snails’ management, nanotechnology has gained more interest.
Results
Copper oxide nanoparticles, characterised by transmission electron microscopy and X-ray diffraction, showed a single crystal structure with an average crystallite size around 40 nm by X-ray diffraction and typical transmission electron microscopy (TEM) image. Also, the UV–VIS spectrophotometer displayed a sharp absorption band of CuO NPs. Molluscicidal activity of copper oxide nanoparticles against B. alexandrina snails was observed. Following exposure to CuO NPs (LC50 and LC90 was 40 and 64.3 mg/l, respectively), there was a reduction in the growth and reproductive rates of treated B. alexandrina at the sub-lethal concentrations, as well as, a drop in egg viability. Moreover, CuO NPs exhibited a toxic effect on miracidiae and cercariae of S. mansoni. Scanning electron microscopy (SEM) investigations of the head-foot and mantle of control and treated snails to the sub-lethal concentrations of CuO NPs (LC10 15.6 mg\l–LC25 27.18 mg\l) indicated morphological alterations in the ultrastructure.
Conclusions
CuO NPs caused a significant effect against the intermediate hosts of S. mansoni and provide a considerable scope in exploiting local indigenous resources as snail molluscicidal agents.
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Agricultural and Biological Sciences (miscellaneous),Medicine (miscellaneous)
Reference58 articles.
1. Kiros G, Erko B, Giday M, Mekonnen Y (2014) Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits. BMC Res Notes 7:1–7
2. Rizk MZ, Aly HF (2015) Recent therapeutic approaches in control of parasitic diseases with special reference to schistosomiasis. - IJAR 1: 957–971.
3. Abou-El-Naga IF, Sadaka HA, Amer EI, Diab IH, Khedr SIA (2015) Impact of the age of Biomphalaria alexandrina snails on Schistosoma mansoni transmission: modulation of the genetic outcome and the internal defence system of the snail. Mem Inst Oswaldo Cruz 110:585–595
4. El-Sheikh YWA, Eltamny HM, Soliman HA, Farag AA, El Behary MHH (2012) Molluscicidal activity of eco-friendly natural compound (Rutin) gained from ethanolic flowers extract of Calendula officinalis on B. alexandrina B truncatus -. NY Sci J 5:19–27
5. Bakry FA, El-Hommossany K, Mossalem HS (2012) Immunological and physiological parameters of Biomphalaria alexandrina snails exposed to Azadirachta indica plant. Eur Rev Med Pharmacol Sci 16:133–143
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