Author:
Wei Wen,Zhang Lingyu,Li Guode,Huang Zhidong,Liu Jin,Wu Zhihuang,Wu Yuanying,Lin Jinrong,Zhang Yunhan,Yu Yaren,Huang Haozhang,Li Qiang,Wang Bo,Liu Yong,Tu Mei,Chen Hong,Chen Shiqun
Abstract
Abstract
Background
Malnutrition is associated with poor prognosis in cardiovascular disease patients or in diabetic patients. However, the relationship between malnutrition and clinical outcomes in diabetic patients with coronary artery disease (CAD) is not well known. The aim of this study is to report the prevalence and prognostic consequences of malnutrition in diabetic patients with CAD.
Methods
In this retrospective observational study, the Controlling Nutritional Status (CONUT) score applied to 12,898 consecutive diabetic patients with CAD. The association between malnutrition and long-term all-cause mortality was examined using Cox proportional hazards regression analysis.
Results
According to CONUT score, 60.5% patients suffered from malnutrition; 46.4%, 13.2%, and 0.9% patients had mild, moderate, and severe malnutrition, respectively. During a median follow-up of 4.88 (2.83–7.51) years, 1973 (15.3%) patients died. After adjustment for confounders, malnutrition was associated with significantly increased risk for long-term all-cause mortality (adjusted hazard ratio for mild malnutrition and moderate to severe malnutrition, respectively: 1.38 [95% confidence interval (CI) 1.07–1.77]; P value = 0.012 and 1.63 [95% CI 1.18–2.24]; P value = 0.003). A similar association was observed around subgroups.
Conclusions
Malnutrition is common in diabetic patients with CAD and is strongly associated with increased mortality. It is necessary to adequately assess the nutritional status and take the effective nutritional guidance to improve the prognosis of diabetic patients with CAD.
Funder
Multi-center study on key techniques for prevention, diagnosis and treatment of high risk coronary artery disease
Study on the function and mechanism of the potential target for early warning of cardiorenal syndrome after acute myocardial infarction based on transmoomics
Natural Science Foundation of Guangdong Province
guangdong provincial science and technology plan project
guangdong provincial fund for clinical medications
Publisher
Springer Science and Business Media LLC
Subject
Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)
Cited by
11 articles.
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