Author:
Niu Yang,Zhao Xue-lin,Ruan Hui-juan,Mao Xiao-meng,Tang Qing-ya
Abstract
Abstract
Background
Current adult studies suggest that uric acid (UA) is associated with body fat, but the relationship in obese children is unclear. Thus, we aim to evaluate the association between uric acid and body composition of obese children.
Methods
A total of 79 obese children were included in this study, and 52 children (34 boys and 18 girls) underwent a 6-week weight loss camp, including 34 boys and 18 girls. Six-week weight-loss interventions were performed on all participants through aerobic exercise and appropriate dietary control. Laboratory tests and body composition were collected before and after the intervention.
Results
Before the intervention, correlation analysis demonstrated that uric acid was positively correlated with height, weight, body mass index (BMI), waist circumference, hip circumference, fat mass (FM), and free fat mass (FFM) with adjusting for age and gender (P < 0.05). After 6 weeks of intervention, the participants gained 3.12 ± 0.85 cm in height, body fat percentage decreased by 7.23 ± 1.97%, and lost 10.30 ± 2.83 kg in weight. Univariate and multivariate analysis indicated that uric acid at baseline was associated with FM reduction during weight loss (P < 0.05).
Conclusions
This study is the first report that uric acid is associated with BMI and FM, and may play an important role in the reduction of FM during weight loss in obese children and adolescents. The interaction between UA and adiposity factors and its underlying mechanisms need to be further explored.
Trial registration
This study was registered in Clinical Trials.gov (NCT03490448) and approved by the Ethics Committee of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.
Funder
Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition
Publisher
Springer Science and Business Media LLC
Subject
Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)
Reference27 articles.
1. Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:766–81.
2. World Health Organization. World Health Statistics 2015. World Health Organization. 2015.
3. Muntner P, Srinivasan S, Menke A, et al. Impact of childhood metabolic syndrome components on the risk of elevlated uric acid in adulthood: The Bogalusa Heart Study. Am J Med Sci. 2008;335(5):332–7.
4. Maliavskaia SI, Lebedev AV, Temovskaia VA. Chronic asymptomatic hyperuricemia as a marker of atherogenic risk in children. Kardiologiia. 2007;47(3):62–6.
5. Alper AB Jr, Chen W, Yau L, et al. Childhood uric acid predicts adult blood pressure: The Bogalusa Heart Study. Hypertension. 2005;45(1):34–8.
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献