Author:
Liu Meifang,Di Yuan Ming,Zhang Anthony Lin,Chen Junhui,Wang Ruobing,Huang Juan,Zhang Lei,Xue Charlie Changli,Liu Xusheng
Abstract
Abstract
Background
Diabetic kidney disease (DKD) is a common and severe complication of diabetes that can lead to end-stage renal disease with no cure. The first-line drugs recommended by clinical guidelines fail to achieve satisfactory effects for people with DKD. A Chinese herbal medicine Tangshen Qushi Formula (TQF) shows preliminary efficacy and safety in preserving renal function for people with DKD, but the effects on comprehensive renal outcomes remain unclear. We will conduct a systematic review and meta-analysis to evaluate the effects of TQF herbs and their compounds identified from ultra-high performance liquid chromatography-MS/MS in diabetic animal models with renal outcomes.
Methods
This protocol complies with the guideline Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. We will include studies investigating the effects of TQF herbs and compounds on diabetic rats or mice with renal outcomes. Six electronic databases will be searched from their inception to February 2023. Quality assessment will be conducted using SYRCLE’s risk of bias tool. Standardized or weighted mean differences will be estimated for renal outcomes (creatinine, urea, proteinuria, histological changes, oxidative stress, inflammation, and kidney fibrosis). Data will be pooled using random-effects models. Heterogeneity across studies will be expressed as I2. Sensitivity analyses will explore treatment effects in adjusted models and within subgroups. Funnel plots and Egger’s test will be used to explore publication bias.
Discussion
The results of this review will provide valuable insights into the potential effects of TQF in managing DKD. The limitation is that the included studies will be animal studies from specific databases, and the interpretation of the findings must be cautious.
Systematic review registration
PROSPERO CRD42023432895. Registered on 19 July 2023 (https://www.crd.york.ac.uk/PROSPERO/#recordDetails).
Funder
The State Key Laboratory of Dampness Syndrome of Chinese Medicine in Guangdong Provincial Hospital of Chinese Medicine
Guangzhou Municipal Science and Technology Project
Publisher
Springer Science and Business Media LLC
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