Abstract
Abstract
Introduction
Malaria presents a significant global public health burden, although substantial progress has been made, with vector control initiatives such as indoor residual surface spraying with insecticides and insecticide-treated nets. There now exists many different approaches to apply residual insecticide to indoor and outdoor surfaces in malaria-endemic settings, although no comprehensive systematic reviews exist evaluating these interventions. This manuscript outlines the protocol for a systematic review which aims to synthesise the best available evidence regarding full or partial indoor or outdoor residual insecticide surface treatment for preventing malaria.
Methods and analysis
This review will comprehensively search the literature (both published and unpublished) for any studies investigating the effectiveness of residual insecticide surface treatment for malaria. Studies will be screened to meet the inclusion criteria by a minimum of two authors, followed by assessment of risk of bias (using appropriate risk-of-bias tools for randomised and non-randomised studies) and extraction of relevant information using structured forms by two independent authors. Meta-analysis will be carried out where possible for epidemiological outcomes such as malaria, anaemia, malaria-related mortality, all-cause mortality and adverse effects. Certainty in the evidence will be established with GRADE assessments.
Ethics and dissemination
A full review report will be submitted to the Vector Control & Insecticide Resistance Unit, Global Malaria Program, WHO. A version of this report will be submitted for publication in an open access peer-reviewed journal. The report will inform the development of WHO recommendations regarding residual insecticide treatment for malaria. This systematic review does not require ethics approval as it is a review of primary studies.
Systematic review registration
PROSPERO 293194.
Funder
World Health Organization
Publisher
Springer Science and Business Media LLC
Reference28 articles.
1. WHO. World malaria report 2020: 20 years of global progress and challenges. Geneva: World Health Organization; 2020.
2. WHO. World malaria report 2021. Geneva: World Health Organization; 2021.
3. Bhatt S, Weiss DJ, Cameron E, et al. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature. 2015;526(7572):207–11. https://doi.org/10.1038/nature15535[publishedOnlineFirst:2015/09/17].
4. WHO. Preferred product characteristics: indoor residual spraying products for malaria transmission control in areas with insecticide-resistant mosquito populations: draft for public consultation. Geneva: World Health Organization; 2021.
5. Lengeler C, Sharp B. Indoor residual spraying and insecticide-treated nets. In: Reducing malarials burden: evidence of effectiveness for decision makers Global Health Council Washington DC; 2003. p. 17–24.