Abstract
Abstract
Background
Over the last decade, computational sciences have contributed immensely to characterization of phenotypes of airway diseases, but it is difficult to compare derived phenotypes across studies, perhaps as a result of the different decisions that fed into these phenotyping exercises. We aim to perform a systematic review of studies using computational approaches to phenotype obstructive airway diseases in children and adults.
Methods and analysis
We will search PubMed, Embase, Scopus, Web of Science, and Google Scholar for papers published between 2010 and 2020. Conferences proceedings, reference list of included papers, and experts will form additional sources of literature. We will include observational epidemiological studies that used a computational approach to derive phenotypes of chronic airway diseases, whether in a general population or in a clinical setting. Two reviewers will independently screen the retrieved studies for eligibility, extract relevant data, and perform quality appraisal of included studies. A third reviewer will arbitrate any disagreements in these processes. Quality appraisal of the studies will be undertaken using the Effective Public Health Practice Project quality assessment tool. We will use summary tables to describe the included studies. We will narratively synthesize the generated evidence, providing critical assessment of the populations, variables, and computational approaches used in deriving the phenotypes across studies
Conclusion
As progress continues to be made in the area of computational phenotyping of chronic obstructive airway diseases, this systematic review, the first on this topic, will provide the state of the art on the field and highlight important perspectives for future works.
Ethics and dissemination
No ethical approval is needed for this work is based only on the published literature and does not involve collection of any primary or human data.
Registration and reporting
Systematic review registration
PROSPERO CRD42020164898
Funder
The Swedish Heart-Lung Foundation
swedish research conucil
Herman Krefting Foundation for Asthma and Allergy Research
Göteborgs Universitet
Västra Götalandsregionen
Umeå Universitet
Västerbotten Läns Landsting
Norrbotten County Council
the Swedish Asthma-Allergy Foundation
Knut and Alice Wallenberg Foundation
Wallenberg Centre for Molecular and Translational Medicine
University of Gothenburg
Publisher
Springer Science and Business Media LLC
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