Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA : A case report and review of the literature-Reference-Cited by-同舟云学术

Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA : A case report and review of the literature

Published:2005-06-08 Issue: Volume:2 Page:8
ISSN:0974-5963
Container-title:CytoJournal
language:en
Short-container-title:

Author:

Bean Sarah M¹,Eloubeidi Mohamad A²,Eltoum Isam A¹,Cerfolio Robert J³,Jhala Darshana N¹

Affiliation:

1. Department of Pathology, Division of Anatomic Pathology, the Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Department of Pathology, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama, USA

3. Department of Cardiothoracic Surgery at the University of Alabama at Birmingham, Birmingham, Alabama, USA

Abstract

We report the first case of a posterior mediastinal granular cell tumor initially diagnosed on cytologic material obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in a 51-year-old male with a prior history of colon cancer. Aspirates obtained were cellular and composed of polygonal cells with abundant granular cytoplasm and small, round dark nuclei. An immunoperoxidase stain performed on the cell block for antibodies to S-100 protein showed strong, diffuse staining of the cytoplasmic granules. Electron microscopy performed on the cell block revealed numerous cytoplasmic lysosomes. This is the first case report in the English literature of a definitive preoperative diagnosis of a mediastinal granular cell tumor utilizing material obtained via EUS-FNA.

Publisher

Scientific Scholar

Subject

Pathology and Forensic Medicine

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