Author:
Guo Ava Jiangyang,Choi Roy Chi-yan,Cheung Anna Wing-han,Li Jun,Chen Ivy Xiaoying,Dong Tina Tingxia,Tsim Karl Wah-keung,Lau Brad Wing-chuen
Abstract
Abstract
Background
Chinese medicine has been proposed as a novel strategy for the prevention of metabolic disorders such as obesity. The present study tested 17 Chinese medicinal herbs were tested for their potential anti-obesity effects.
Methods
The herbs were evaluated in terms of their abilities to stimulate the transcription of Apolipoprotein A-IV (ApoA-IV) in cultured Caco-2/TC7 enterocytes. The herbs that showed stimulating effects on ApoA-IV transcription were further evaluated in terms of their abilities to reduce the formation of triglyceride in differentiated 3T3-L1 adipocytes.
Results
ApoA-IV transcription was stimulated by Rhizoma Alismatis and Radix Angelica Sinensis in a dose- and time-dependent manner in cultured Caco-2/TC7 cells. Moreover, these two herbs reduced the amount of triglyceride in differentiated 3T3-L1 adipocytes.
Conclusion
The results suggest that Rhizoma Alistmatis and Radix Angelica Sinensis may have potential anti-obesity effects as they stimulate ApoA-IV transcription and reduce triglyceride formation.
Publisher
Springer Science and Business Media LLC
Subject
Complementary and alternative medicine,Pharmacology
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