Author:
Chai Stella,To Kenneth KW,Lin Ge
Abstract
Abstract
Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents.
Publisher
Springer Science and Business Media LLC
Subject
Complementary and alternative medicine,Pharmacology
Reference120 articles.
1. Meszaros A, Balogh G: Multiple Drug Resistance. 2009, Lancaster, UK: Gazelle Distribution
2. Biedler JL, Riehm H: Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies. Cancer Res. 1970, 30: 1174-1184.
3. Gottesman MM: Mechanisms of cancer drug resistance. Annu Rev Med. 2002, 53: 615-617. 10.1146/annurev.med.53.082901.103929.
4. La Porta CAM: Drug resistance in melanoma: new perspectives. Curr Med Chem. 2007, 14 (4): 387-91. 10.2174/092986707779941078.
5. Watson JV: Introduction to Flow Cytometry. 1991, Cambridge: Cambridge University Press
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