Tailoring inputs to achieve maximal neuronal firing

Abstract

Abstract We consider the constrained optimization of excitatory synaptic input patterns to maximize spike generation in leaky integrate-and-fire (LIF) and theta model neurons. In the case of discrete input kicks with a fixed total magnitude, optimal input timings and strengths are identified for each model using phase plane arguments. In both cases, optimal features relate to finding an input level at which the drop in input between successive spikes is minimized. A bounded minimizing level always exists in the theta model and may or may not exist in the LIF model, depending on parameter tuning. We also provide analytical formulas to estimate the number of spikes resulting from a given input train. In a second case of continuous inputs of fixed total magnitude, we analyze the tuning of an input shape parameter to maximize the number of spikes occurring in a fixed time interval. Results are obtained using numerical solution of a variational boundary value problem that we derive, as well as analysis, for the theta model and using a combination of simulation and analysis for the LIF model. In particular, consistent with the discrete case, the number of spikes in the theta model rises and then falls again as the input becomes more tightly peaked. Under a similar variation in the LIF case, we numerically show that the number of spikes increases monotonically up to some bound and we analytically constrain the times at which spikes can occur and estimate the bound on the number of spikes fired.