Author:
Zhou Yongfeng,Wang Junnan,Zhang Dingkun,Liu Jiaxin,Wu Qinghua,Chen Jiang,Tan Peng,Xing Boyu,Han Yanzhong,Zhang Ping,Xiao Xiaohe,Pei Jin
Abstract
AbstractDrug-induced liver injury (DILI) is a common adverse drug reaction (ADR) and a serious threat to health that affects disease treatments. At present, no targeted clinical drugs are available for DILI. Traditional natural medicines have been widely used as health products. Some natural medicines exert specific hepatoprotective effects, with few side effects and significant clinical efficacy. Thus, natural medicines may be a promising direction for DILI treatment. In this review, we summarize the current knowledge, common drugs and mechanisms of DILI, as well as the clinical trials of natural drugs and their bioactive components in anticipation of the future development of potential hepatoprotective drugs.
Funder
National Key R&D Program of China
Publisher
Springer Science and Business Media LLC
Subject
Complementary and alternative medicine,Pharmacology