Abstract
AbstractAs a Traditional Chinese Medicine, Eucommia ulmoides Oliv. has been used for the treatment of various diseases since ancient times, involving lumbar pain, knee pain, osteoporosis, hepatoprotection, paralysis, intestinal haemorrhoids, vaginal bleeding, abortion, spermatorrhoea, foot fungus, anti-aging etc. With the developing discovery of E. ulmoides extracts and its active components in various pharmacological activities, E. ulmoides has gained more and more attention. Up to now, E. ulmoides has been revealed to show remarkable therapeutic effects on hypertension, hyperglycemia, diabetes, obesity, osteoporosis, Parkinson’s disease, Alzheimer’s disease, sexual dysfunction. E. ulmoides has also been reported to possess antioxidant, anti-inflammatory, neuroprotective, anti-fatigue, anti-aging, anti-cancer and immunoregulation activities etc. Along these lines, this review summarizes the traditional application and modern pharmacological research of E. ulmoides, providing novel insights of E. ulmoides in the treatment of various diseases.
Funder
National Natural Science Foundation of China
Traditional Chinese Medicine Key Scientific Research Fund Project of Zhejiang Province
Program of China
Publisher
Springer Science and Business Media LLC
Subject
Complementary and alternative medicine,Pharmacology
Reference147 articles.
1. Liu PF, Wang L, Du QX. Estimation of potential suitable distribution area and the ecological characteristics of Eucommia ulmoides Oliv. in China. Acta Ecol Sin. 2020;98:5674–84.
2. Habtemariam S, Lentini G. Plant-derived anticancer agents: lessons from the pharmacology of geniposide and its aglycone genipin. Biomedicines. 2018;6:2.
3. Zeng X, Guo F, Ouyang D. A review of the pharmacology and toxicology of aucubin. Fitoterapia. 2020;140:104443.
4. Sih CJ, Ravikumar PR, Huang FC, Buckner C, Whitlock H Jr. Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung (Eucommia ulmoides, Oliver). J Am Chem Soc. 1976;98(17):5412–3.
5. Shchepotin BM, Shchulipenko IM. Treatment of patients with hypertension with an extract of the leaves of Eucommia ulmoides. Vrach Delo. 1983;1:30.