Abstract
AbstractEthanol precipitation is a purification process widely used in the purification of Chinese medicine concentrates. This article reviews the research progress on the process mechanism of ethanol precipitation, ethanol precipitation process application for bioactive component purification, ethanol precipitation and traditional Chinese medicine quality, ethanol precipitation equipment, critical parameters, parameter research methods, process modeling and calculation methods, and process monitoring technology. This review proposes that ethanol precipitation technology should be further developed in terms of five aspects, namely, an in-depth study of the mechanism, further study of the effects on traditional Chinese medicine quality, improvement of the quality control of concentrates, development of new process detection methods, and development of a complete intelligent set of equipment.
Funder
National Major Science and Technology Projects of China
Zhejiang Province Public Welfare Technology Application Research Project
National Project for Standardization of Chinese Materia Medica
Publisher
Springer Science and Business Media LLC
Subject
Complementary and alternative medicine,Pharmacology
Reference155 articles.
1. Gong XC, Wang SS, Qu HB. Comparison of two separation technologies applied in the manufacture of botanical injections: second ethanol precipitation and solvent extraction. Ind Eng Chem Res. 2011;50(12):7542–8.
2. Gong XC, Li Y, Qu HB. Removing tannins from medicinal plant extracts using an alkaline ethanol precipitation process: a case study of Danshen injection. Molecules. 2014;19(11):18705–20.
3. Shao F, Yu MY, Jiang ML, Yang M, Shang Y, Liu RH, et al. Establishment of determination of fractal dimension of ethanol-precipitated flocs of two root medicinal herbs. Chin J Exp Med Formul. 2019;25(22):103–7 (in Chinese).
4. State Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China, vol. 1. Beijing: China Medical Science Press; 2015.
5. Bouchard A, Hofland GW, Witkamp GJ. Properties of sugar, polyol, and polysaccharide water–ethanol solutions. J Chem Eng Data. 2007;52(5):1838–42.
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献