A double blind randomized placebo controlled phase I/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia

Author:

Gupta Pawan K,Chullikana Anoop,Parakh Rajiv,Desai Sanjay,Das Anjan,Gottipamula Sanjay,Krishnamurthy Sagar,Anthony Naveen,Pherwani Arun,Majumdar Anish S

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference39 articles.

1. Sprengers RW, Lips DJ, Moll FL, Verhaar MC: Progenitor cell therapy in patients with critical limb ischemia without surgical options. Ann Surg. 2008, 13: 411-420.

2. Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL, Hiratzka LF, Murphy WRC, Olin JW, Puschett JB, Rosenfield KA, Sacks D, Stanley JC, Taylor LM, White CJ, White J, White RA, Antman EM, Smith SC, Adams CD, Anderson JL, Faxon DP, Fuster V, Gibbons RJ, Halperin JL, Hiratzka LF, Hunt SA, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B: ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary a collaborative report from the American association for vascular surgery/society for vascular surgery, society for cardiovascular angiography and interventions, society for vascular medicine and biology, society of interventional radiology, and the ACC/AHA task force on practice guidelines (writing committee to develop guidelines for the management of patients with peripheral arterial disease) endorsed by the American association of cardiovascular and pulmonary rehabilitation; national heart, lung, and blood institute; society for vascular nursing; TransAtlantic inter-society consensus; and vascular disease foundation. J Am Coll Cardiol. 2006, 47: 1239-1312. 10.1016/j.jacc.2005.10.009.

3. Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FGR: Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg. 2007, 45 (Suppl S): S5-S67.

4. The European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products: Note for guidance on clinical investigation of medicinal products for the treatment of peripheral arterial occlusive disease. CPMP/EWP/714/98 REV. 2002, 1: 1-16.

5. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM: Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997, 275: 964-967. 10.1126/science.275.5302.964.

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