Author:
Liang Qiong-Lin,Liang Xiao-Ping,Wang Yi-Ming,Xie Yuan-Yuan,Zhang Rong-Li,Chen Xi,Gao Rong,Cheng Yi-Jun,Wu Jun,Xu Qing-Bo,Xiao Qing-Zhong,Li Xue,Lv Shu-Feng,Fan Xue-Mei,Zhang Hong-Yang,Zhang Qing-Li,Luo Guo-An
Abstract
Abstract
Background
Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF.
Method
In this study, we present a "system to system" (S2S) mode. Based on this mode, SLF was simplified successively through bioactivity-guided screening to achieve an optimized minimal phytochemical composition (new formula NSLF6) while maintaining its curative effect for MI.
Results
Pharmacological test combining with the study of systems biology show that NSLF6 has activity for treatment MI through synergistic therapeutic efficacies between total ginsenosides and total salvianolic acids via promoting cardiac cell regeneration and myocardial angiogenesis, antagonistic myocardial cell oxidative damage.
Conclusions
The present S2S mode may be an effective way for the discovery of new composite drugs from traditional medicines.
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
21 articles.
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