Evaluation of nasal symptoms induced by platelet activating factor, after nasal challenge in both healthy and allergic rhinitis subjects pretreated with rupatadine, levocetirizine or placebo in a cross-over study design

Author:

Muñoz-Cano Rosa,Valero Antonio,Izquierdo Ignacio,Sánchez-López Jaume,Doménech Alejandro,Bartra Joan,Mullol Joaquim,Picado Cesar

Publisher

Springer Science and Business Media LLC

Subject

Pulmonary and Respiratory Medicine,Immunology,Immunology and Allergy

Reference17 articles.

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2. Merlos M, Giral M, Balsa D, Ferrando R, Queralt M, Puigdemont A, Garcia Rafanell J, Forn J: Rupatadine, a new potent, orally active dual antagonist of histamine and platelet activating factor (PAF). J Pharmacol Exp Ther. 1997, 280: 114-121.

3. Leggieri E, Tedeschi A, Lorini M, Bianco A, Miadonna A: Study of the effects of paf-acheter on human nasal airways. Allergy. 1991, 6: 466-471.

4. Tedeschi A, Palumbo G, Milazzo N, Miadonna A: Nasal neutrophilia and esosinophilia induced by challenge with platelet activating factor. J Allergy Clin Immunol. 1994, 2: 526-533.

5. Klementsson H, Andersson M: Eosinophil chemotactic activity of topical PAF on the human nasal mucosa. Eur J Clin Pharmacol. 1992, 3: 295-299.

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