Author:
Gilles Stefanie,Mariani Valentina,Bryce Martina,Mueller Martin J,Ring Johannes,Behrendt Heidrun,Jakob Thilo,Traidl-Hoffmann Claudia
Abstract
Abstract
Pollen allergy is characterized by a TH2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather a plethora of protein and non-protein substances. We demonstrated that pollen liberate lipids with chemical and functional similarities to leukotriens and prostaglandins - the pollen associated lipid mediators (PALMs). To date, two main groups of PALMs have been characterized: The immunostimulatory PALMs activating innate immune cells such as neutrophils and eosinophils, and the immunomodulatory E1-phytoprostanes blocking IL-12 production of dendritic cells, resulting in the preferential induction of TH2 responses. This article reviews our work in the field of PALMs and their effects on cells of the innate and adoptive immune system. From recent results a general picture starts to emerge in which PALMs (and possibly other pollen-associated substances) may - independently from protein allergens - propagate an overall TH2 favoring micromilieu in pollen exposed tissue of predisposed individuals.
Publisher
Springer Science and Business Media LLC
Subject
Pulmonary and Respiratory Medicine,Immunology,Immunology and Allergy
Reference30 articles.
1. Chapman MD, Wunschmann S, Pomes A: Proteases as Th2 adjuvants. Curr Allergy Asthma Rep. 2007, 7: 363-367. 10.1007/s11882-007-0055-6.
2. Comoy EE, Pestel J, Duez C, Stewart GA, Vendeville C, Fournier C, Finkelman F, Capron A, Thyphronitis G: The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gamma. J Immunol. 1998, 160: 2456-2462.
3. Traidl-Hoffmann C, Jakob T, Behrendt H: Determinants of allergenicity. J Allergy Clin Immunol. 2008, 123: 558-566. 10.1016/j.jaci.2008.12.003.
4. Boldogh I, Bacsi A, Choudhury BK, Dharajiya N, Alam R, Hazra TK, Mitra S, Goldblum RM, Sur S: ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest. 2005, 115: 2169-2179. 10.1172/JCI24422.
5. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K: Immunobiology of dendritic cells. Annu Rev Immunol. 2000, 18: 767-811. 10.1146/annurev.immunol.18.1.767.
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