Preparing for cell culture scale-out: establishing parity of bioreactor- and flask-expanded mesenchymal stromal cell cultures
Author:
Funder
FP7 Research for the Benefit of SMEs
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://link.springer.com/content/pdf/10.1186/s12967-019-1989-x.pdf
Reference33 articles.
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3. Heathman TRJ, Nienow AW, McCall MJ, Coopman K, Kara B, Hewitt CJ. The translation of cell-based therapies: clinical landscape and manufacturing challenges. Regen Med. 2015;10:49–64. https://doi.org/10.2217/rme.14.73 .
4. Bubela T, McCabe C, Archibald P, Atkins H, Bradshaw SE, Kefalas P, et al. Bringing regenerative medicines to the clinic: the future for regulation and reimbursement. Regen Med. 2015;10:897–911. https://doi.org/10.2217/rme.15.51 .
5. Hourd P, Ginty P, Chandra A, Williams DJ. Manufacturing models permitting roll out/scale out of clinically led autologous cell therapies: regulatory and scientific challenges for comparability. Cytotherapy. 2014;16:1033–47. https://doi.org/10.1016/j.jcyt.2014.03.005 .
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