Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail

Author:

Pound PandoraORCID,Ritskes-Hoitinga Merel

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference75 articles.

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3. Hay M, Thomas DW, Craighead JL, Economides C, Rosenthal J. Clinical development success rates for investigational drugs. Nat Biotechnol. 2014;32(1):40.

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5. Deloitte. A new future for R&D? Measuring the return from pharmaceutical innovation 2017. 2017. https://www2.deloitte.com/content/dam/Deloitte/uk/Documents/life-sciences-health-care/deloitte-uk-measuring-roi-pharma.pdf . Accessed 10 July 2018.

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